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KMID : 0939920210530030763
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대한암학회지
2021 Volume.53 No. 3 p.763 ~ p.772
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Development and Validation of a Symptom-Focused Quality of Life Questionnaire (KOQUSS-40) for Gastric Cancer Patients after Gastrectomy
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Eom Bang-Wool
Lee Joong-Yub
Lee In-Seob
Son Young-Gil
Ryu Keun-Won
Kim Sung-Geun
Kim Hyoung-Il
Kim Young-Woo
Kong Seong-Ho
Kwon Oh-Kyoung
Park Ji-Ho
An Ji-Yeong
Kim Chang-Hyun
Suh Byoung-Jo
Yoon Hong-Man
Son Myoung-Won
Park Ji-Yeon
Park Jong-Min
Jeong Sang-Ho
Yoo Moon-Won
Song Geum-Jong
Yang Han-Kwang
Suh Yun-Suhk
Park Ki-Bum
Ahn Sang-Hoon
Shin Dong-Woo
Jee Ye-Seob
Ahn Hye-Seong
Lee Sol
Min Jae-Seok
In Hae-Jin
Kim Ah-Young
Hur Hoon
Lee Hyuk-Joon
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Abstract
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Purpose: Patients who have undergone gastrectomy have unique symptoms that are not appropriately assessed using currently available tools. This study developed and validated a symptom-focused quality of life (QoL) questionnaire for patients who have received gastrectomy for gastric cancer.
Materials and Methods: Based on a literature review, patient interviews, and expert consultation by the KOrean QUality of life in Stomach cancer patients Study group (KOQUSS), the initial item pool was developed. Two large-scale developmental studies were then sequentially conducted for exploratory factor analyses for content validity and item reduction. The final item pool was validated in a separate cohort of patients and assessed for internal consistency, test-retest reliability, construct validity, and clinical validity.
Results: The initial questionnaire consisted of 46-items in 12 domains. Data from 465 patients at 11 institutions, followed by 499 patients at 13 institutions, were used to conduct item reduction and exploratory factor analyses. The final questionnaire (KOQUSS-40) comprised 40 items within 11 domains. Validation of KOQUSS-40 was conducted on 413 patients from 12 hospitals. KOQUSS-40 was found to have good model fit. The mean summary score of the KOQUSS-40 was correlated with the EORTC QLQ-C30 and STO22 (correlation coefficients, 0.821 and 0.778, respectively). The KOQUSS-40 score was also correlated with clinical factors, and had acceptable internal consistency (> 0.7). Test-retest reliability was greater than 0.8.
Conclusion: The KOQUSS-40 can be used to assess QoL of gastric cancer patients after gastrectomy and allows for a robust comparison of surgical techniques in clinical trials.
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KEYWORD
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Stomach neoplasms, Quality of life, Surveys and questionnaires, Validation study
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